Desoxyrhaponticin

Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects[1][2].

Product Specifications

CAS Number

[30197-14-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Fatty Acid Synthase (FASN)

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/desoxyrhaponticin.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

COC(C=C1)=CC=C1/C=C/C2=CC(O)=CC(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)=C2

Molecular Formula

C21H24O8

Molecular Weight

404.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Li P, et al. Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.|[2]Li JM, et al. Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies. J Pharmacol Exp Ther. 2007 Jan;320 (1) :38-46.