TFLLR-NH2 (TFA)
TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.
Product Specifications
CAS Number
1313730-19-6
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Protease Activated Receptor (PAR)
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/TFLLR-NH2_TFA_.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O.FC(C(O)=O)(F)F
Molecular Formula
C33H54F3N9O8
Molecular Weight
761.83
Precautions
H302, H315, H319, H335
References & Citations
[1]de Garavilla L, et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001 Aug;133 (7) :975-87.|[2]Kawabata A, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.|[3]Jia Y, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncol Rep. 2015 Jun;33 (6) :2681-8.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
PAR1
Citation 01
BioRxiv. 2024 Jul 26:2024.07.26.605282.|Res Sq. 2024 Sep 04.|Cells. 2023 May 24;12 (11) :1461.
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