TFLLR-NH2 (TFA)

TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.

Product Specifications

CAS Number

[1313730-19-6]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Protease Activated Receptor (PAR)

Type

Peptides

Related Pathways

GPCR/G Protein

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/TFLLR-NH2_TFA_.html

Purity

99.62

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O.FC(C(O)=O)(F)F

Molecular Formula

C33H54F3N9O8

Molecular Weight

761.83

Precautions

H302, H315, H319, H335

References & Citations

[1]de Garavilla L, et al. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. Br J Pharmacol. 2001 Aug;133 (7) :975-87.|[2]Kawabata A, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle.|[3]Jia Y, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Oncol Rep. 2015 Jun;33 (6) :2681-8.