2B- (SP) (TFA)
2B- (SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3) . 2B- (SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3[1].
Product Specifications
UNSPSC
12352209
Target
GSK-3
Type
Peptides
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2b-sp-tfa.html
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](COP(O)(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C71H123N26O29P.xC2HF3O2
Molecular Weight
1835.87 (free acid)
References & Citations
[1]G I Welsh, et al. Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.Anal Biochem. 1997 Jan 1;244 (1) :16-21.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
GSK-3α; GSK-3β
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