2B-(SP) (TFA)
Product Specifications
UNSPSC Description
2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3[1].
Target Antigen
GSK-3
Type
Peptides
Related Pathways
PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2b-sp-tfa.html
Solubility
10 mM in DMSO
Smiles
N=C(N)NCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(N[C@@H](COP(O)(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Weight
1835.87 (free acid)
References & Citations
[1]G I Welsh, et al. Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts.Anal Biochem. 1997 Jan 1;244(1):16-21.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1114A/2B-SP-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1114A/
Clinical Information
No Development Reported
Curated Selection
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