Human α-Defensin 6
Human α-Defensin 6, a 32-residue cysteine-rich peptide, can inhibit bacterial invasion and contribute to the mucosal immunity. Human α-Defensin 6 forms ordered self-assembly fibrils and nanonets that surround and entangle bacteria after stochastic binding to bacterial surface proteins. Human α-Defensin 6 also inhibits C. albicans biofilm formation[1][2].
Product Specifications
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/human-α-defensin-6.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(C)C)C(O)=O)=O)NC2=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CSSC[C@@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCCNC(N)=N)C(N[C@H]5CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H]2NC5=O)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC9=CC=C(C=C9)O)C(N[C@@H](CO)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(NCC(N[C@H]7[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C156H228N46O46S7
Molecular Weight
3708.22
References & Citations
[1]Chu H, et al. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27;337 (6093) :477-81.|[2]Chairatana P, et al. Human α-Defensin 6: A Small Peptide That Self-Assembles and Protects the Host by Entangling Microbes. Acc Chem Res. 2017 Apr 18;50 (4) :960-967.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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