VTP50469 (fumarate)
Product Specifications
Product Name Alternative
Disodium (R)-2-hydroxyglutarate
UNSPSC Description
VTP50469 fumarate is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 fumarate has potently anti-leukemia activity[1][2].
Target Antigen
Apoptosis; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vtp50469-fumarate.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C(O)=O.O=C(N(C(C)C)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@H](NS(=O)(C)=O)CC5)CC4)C3.[3/2]
Molecular Weight
804.93
References & Citations
[1]Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36(6):660-673.e11.|[2]Andrei V. Krivtsov, et al. Abstract 4958: VTP50469 is a novel, orally available menin-MLL1 inhibitor effective against MLL-rearranged and NPM1-mutant leukemia. Cancer Resceach. July 2018.Volume 78, Issue 13 Supplement.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114162A/VTP50469-fumarate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114162A/VTP50469-fumarate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2169919-29-1
Available Sizes
Curated Selection
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