[8]-Shogaol

[8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) [1][2][3][4].

Product Specifications

CAS Number

[36700-45-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; COX

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-shogaol.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCC/C=C/C(CCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C19H28O3

Molecular Weight

304.42

Precautions

H302

References & Citations

[1]Shieh PC, et al. Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. J Agric Food Chem. 2010 Mar 24;58 (6) :3847-54.|[2]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[3]Nurtjahja-Tjendraputra E, et al. Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111 (4-5) :259-65.|[4]Jo S, et al. 8-Shogaol inhibits rheumatoid arthritis through targeting TAK1. Pharmacol Res. 2022 Apr;178:106176.