Olmesartan

Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure[1][2].

Product Specifications

CAS Number

[144689-24-7]

Product Name Alternative

RNH-6270

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Olmesartan.html

Purity

99.91

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

O=C(O)C1=C(N=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=NN4)CCC)C(O)(C)C

Molecular Formula

C24H26N6O3

Molecular Weight

446.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131 (3) :190-7.|[2]Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang (1-7) /Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67 (6) :503-9.|[3]Bakhtiari E, et al. Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line. Toxicol Mech Methods. 2015;25 (8) :614-21.