S6K2-IN-1
S6K2-IN-1 (Compound 2) is a S6K2 inhibitor (IC50: 22 nM) . S6K2-IN-1 also inhibits FGFR4 (IC50: 216 nM) . S6K2-IN-1 has acceptable stability in mouse liver microsomes[1].
Product Specifications
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s6k2-in-1.html
Purity
98.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC=C([N+]([O-])=O)C(NC2=NC(N3CCN(CC4=NC5=C(C=CC(C(F)(F)F)=C5)N4)CC3)=C(CC)C=N2)=N1
Molecular Formula
C24H23ClF3N9O2
Molecular Weight
561.95
References & Citations
[1]Gerstenecker S, et al. Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2) . Cancers (Basel) . 2021 Oct 13;13 (20) :5133.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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