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(S) -LTGO-33

(S) -LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S) -LTGO-33 can be used in the treatment of pain disorders[1].

Product Specifications

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-ltgo-33.html

Purity

99.41

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

FC1=CC(C)=C(OC2=NC=C(C=C2C(NC3=CC=CC([S@@](=O)(C)=N)=C3)=O)C(F)(F)F)C=C1

Molecular Formula

C21H17F4N3O3S

Molecular Weight

467.44

References & Citations

[1]Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105 (3) :233-249.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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