(S) -LTGO-33
(S) -LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S) -LTGO-33 can be used in the treatment of pain disorders[1].
Product Specifications
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-ltgo-33.html
Purity
99.41
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
FC1=CC(C)=C(OC2=NC=C(C=C2C(NC3=CC=CC([S@@](=O)(C)=N)=C3)=O)C(F)(F)F)C=C1
Molecular Formula
C21H17F4N3O3S
Molecular Weight
467.44
References & Citations
[1]Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105 (3) :233-249.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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