DMTr-LNA-C (Bz) -3-CED-phosphoramidite
DMTr-LNA-C (Bz) -3-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[206055-78-9]
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmtr-lna-c-bz-3-ced-phosphoramidite.html
Purity
98.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
[H][C@@]12[C@H](N3C(N=C(NC(C4=CC=CC=C4)=O)C=C3)=O)O[C@@]([C@H]2OP(N(C(C)C)C(C)C)OCCC#N)(COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)CO1
Molecular Formula
C47H52N5O9P
Molecular Weight
861.92
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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