N-Boc-4-hydroxy-L-proline methyl ester

N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

Product Specifications

CAS Number

[102195-79-9]

UNSPSC

12352203

Hazard Statement

H302, H315, H317, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-boc-cis-4-hydroxy-l-proline-methyl-ester.html

Purity

99.63

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@H](C(OC)=O)C[C@H](O)C1)OC(C)(C)C

Molecular Formula

C11H19NO5

Molecular Weight

245.28

Precautions

H302, H315, H317, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.