ASK1-IN-6

ASK1-IN-6 is a selective, orally active, and blood-brain barrier penetrant inhibitor of ASK1 (biochemical IC50: 7 nM; cellular IC50: 25 nM) . ASK1-IN-6 exhibits anti-inflammatory and can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1].

Product Specifications

CAS Number

[2407451-82-3]

UNSPSC

12352005

Target

ASK1; Interleukin Related

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ask1-in-6.html

Purity

98.13

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)(F)[C@@H](N1C(C2=CC=CC(NC(C3=C(N=CC(F)=C3)OC)=O)=N2)=NN=C1)C

Molecular Formula

C17H14F4N6O2

Molecular Weight

410.33

References & Citations

[1]Jones JH, et al., Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo. J Med Chem. 2021 Oct 28;64 (20) :15402-15419.