Avatrombopag (maleate)
Avatrombopag (AKR-501) maleate is an orally active, non-peptide thrombopoietin receptor (TPO receptor) agonist (EC50: 3.3 nM) . Avatrombopag maleate mimics the biological activity of TPO. Avatrombopag maleate increases platelet production by activating intracellular signaling systems and promotes the production of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate is a substrate for cytochrome P450 (CYP) 2C9 and CYP3A [1][2][3].
Product Specifications
CAS Number
677007-74-8
Product Name Alternative
AKR-501 (maleate) ; E5501 (maleate) ; YM477 (maleate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Cytochrome P450; ERK; STAT; Thrombopoietin Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/avatrombopag-maleate.html
Purity
99.88
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O.O=C(O)/C=C\C(O)=O
Molecular Formula
C33H38Cl2N6O7S2
Molecular Weight
765.73
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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