IRL-1620 (TFA)
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM[1].
Product Specifications
UNSPSC
12352209
Target
Endothelin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/irl-1620-tfa.html
Purity
98.73
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C(C(O)=O)(F)(F)F.C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)C(C)C)=O)=O)CC3=CC=CC=C3)=O)C)=O)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=4C=5C(NC4)=CC=CC5
Molecular Formula
C88H118F3N17O29
Molecular Weight
1934.97
References & Citations
[1]Takai M, et al. A potent and specific agonist, Suc-[Glu9, Ala11,15]-endothelin-1 (8-21), IRL 1620, for the ETB receptor. Biochem Biophys Res Commun. 1992 Apr 30;184 (2) :953-9.|[2]Briyal S, et al. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015 Aug 20;301:1-11.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
ETB
Available Sizes
Curated Selection
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