PROTAC SARS-CoV-2 Mpro degrader-2
PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 Mpro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM) . PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM[1].
Product Specifications
CAS Number
3057294-32-0
UNSPSC
12352005
Target
PROTACs; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/protac-sars-cov-2-mpro-degrader-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C(N2C3=CC=C(OC)C=C3C(CC(N4CCN(CC4)CC(N[C@H](C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)C(C)(C)C)=O)=O)=C2C)=O)C=C1
Molecular Formula
C48H56ClN7O7S
Molecular Weight
910.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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