L-Histidine-13C6,15N3
L-Histidine-13C6,15N3 is 13C and 15N-labeled L-Histidine. L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
Product Specifications
CAS Number
741656-40-6
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Mitochondrial Metabolism
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-histidine-13c6-15n3.html
Solubility
10 mM in DMSO
Smiles
[15NH2][13C@H]([13C](O)=O)[13CH2][13C]1=[13CH][15NH][13CH]=[15N]1
Molecular Formula
13C6H9 15N3O2
Molecular Weight
164.09
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9 (11) :e112141.|[3]Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176 (3) :1400-8.|[4]Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144 (10) :1637-41.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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