TRPM4-IN-1
TRPM4-IN-1 (CBA) is a potent and selective inhibitor of the cation channel TRPM4, with an IC50 of 1.5 μM. TRPM4-IN-1 can be used for the research of cardiac diseases and prostate cancer[1][2].
Product Specifications
CAS Number
[351424-20-9]
Product Name Alternative
CBA
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trpm4-in-1.html
Purity
99.98
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(Cl)C=C1NC(COC2=CC=CC=C2Cl)=O
Molecular Formula
C15H11Cl2NO4
Molecular Weight
340.16
Precautions
H302, H312, H332
References & Citations
[1]Lijo Cherian Ozhathil, et al. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br J Pharmacol. 2018 Jun; 175 (12) : 2504–2519.|[2]Clémence Delalande, et al. Optimizing TRPM4 inhibitors in the MHFP6 chemical space. Eur J Med Chem. 2019 Mar 15;166:167-177.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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