SHIP1 activator 1
SHIP1 activator 1 is an SH3 domain-containing inositol 5-phosphatase regulator with SHIP1 activating activity. SHIP1 activator 1 retains its SHIA-1 activating ability by removing unnecessary functional groups. SHIP1 activator 1 is able to activate SHIP1 in vitro, inhibit Akt phosphorylation in MOLT-4 cells, and show dose-dependent activity in a mouse model of inflammation. SHIP1 activator 1 is an important chemical tool for evaluating the potential of SHIP1 activators as inhibitors of hematopoietic diseases involving abnormal PI3K cell signaling[1].
Product Specifications
CAS Number
1000010-33-2
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ship1-activator-1.html
Smiles
OC1=CC(O)=CC2=C1[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2
Molecular Formula
C21H30O2
Molecular Weight
314.46
References & Citations
[1]Synthesis of SHIP1-Activating Analogs of the Sponge Meroterpenoid Pelorol
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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