Ac-Pro-Gly-Pro-OH

Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and can be used as CXCR2 agonist. Ac-Pro-Gly-Pro-OH elicits bactericidal activity and inhibits lung inflammation, reducing immune cell apoptosis. Ac-Pro-Gly-Pro-OH enhances the production of type 1 cytokines (IFN-γ and IL-12) but inhibits the production of proinflammatory cytokines. Ac-Pro-Gly-Pro-OH has the potential for the research of sepsis[1][2].

Product Specifications

CAS Number

[292171-04-1]

UNSPSC

12352209

Hazard Statement

H302

Target

CXCR

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-pro-gly-pro-oh.html

Purity

99.49

Solubility

H2O : 50 mg/mL

Smiles

O=C(N1[C@@H](CCC1)C(O)=O)CNC([C@H]2N(CCC2)C(C)=O)=O

Molecular Formula

C14H21N3O5

Molecular Weight

311.33

Precautions

H302

References & Citations

[1]Patel DF, et al The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27 (148) :180017.|[2]Kim SD, et al. Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis. Am J Respir Crit Care Med. 2011 Jul 15;184 (2) :243-51.