Cordycepin

Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2].

Product Specifications

CAS Number

[73-03-0]

Product Name Alternative

3'-Deoxyadenosine

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Antibiotic; Autophagy; Bacterial; MMP; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Cordycepin.html

Purity

99.95

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H]1C[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O1

Molecular Formula

C10H13N5O3

Molecular Weight

251.25

Precautions

H301+H311+H331

References & Citations

[1]Noh EM, et al. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford) . 2009 Jan;48 (1) :45-8.|[2]Huang F, et al. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. PLoS One. 2019 Jun 14;14 (6) :e0218449.