RSK4-IN-1 (TFA)
RSK4-IN-1 TFA is a potent RSK4 inhibitor with a IC50 value of 9.5 nM. RSK4-IN-1 TFA has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rsk4-in-1-tfa.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
CC(C)(C1=CN=C(N=C1N2C3CCCC3)NC4=CC(F)=C(C(F)=C4)O)OC2=O.O=C(O)C(F)(F)F
Molecular Formula
C21H21F5N4O5
Molecular Weight
504.41
References & Citations
[1]Yuan Y, et al. Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma. J Med Chem. 2021 Sep 23;64 (18) :13572-13587.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RSK4
Available Sizes
Frequently Asked Questions
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