Cyanopindolol

Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively) [1][2][3].

Product Specifications

CAS Number

[69906-85-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cyanopindolol.html

Concentration

10mM

Purity

99.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(NCC(O)COC1=CC=CC2=C1C=C(C#N)N2)C

Molecular Formula

C16H21N3O2

Molecular Weight

287.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Hoey A, et al. Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br J Pharmacol. 1996 Feb;117 (4) :712-6. |[2]Schlicker E, et al. Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331 (4) :398-401. |[3]Langlois M, et al. Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. Eur J Pharmacol. 1993 Jan 4;244 (1) :77-87.