Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Drotaverine (hydrochloride)

Product Specifications

UNSPSC Description

Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.

Target Antigen

Calcium Channel; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/drotaverine-hydrochloride.html

Purity

99.65

Solubility

DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 100 mg/mL (ultrasonic)

Smiles

CCOC1=CC2=C(C=C1OCC)CCN/C2=C\C3=CC=C(OCC)C(OCC)=C3.[H]Cl

Molecular Weight

433.97

References & Citations

[1]Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169. |[2]Zsuzsanna Tömösközi, et al. Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes. Eur J Pharmacol. 2002 Aug 2;449(1-2):55-60.|[3]Samra Nazir, et al. Drotaverine Inhibitor of PDE4: Reverses the Streptozotocin Induced Alzheimer's Disease in Mice. Neurochem Res. 2021 Jul;46(7):1814-1829.|[4]Athanas D. Kristev, et al. Comparing hyoscine and drotaverine effects on colon in CT colonography. Cent. Eur. J. Med.6(2) . 2011 . 234-242|[5]Ioana Z Pavel, et al. Drotaverine - a Concealed Cytostatic!.Arch Pharm (Weinheim). 2017 Jan;350(1).

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-108974/Drotaverine-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-108974/Drotaverine-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

Launched

CAS Number

985-12-6

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Benzyltriphenylphosphonium chloride
sc-239335 25 g

Benzyltriphenylphosphonium chloride

Ask
View Details
Human MICAL2 shRNA Plasmid
abx956422-01 150 µg

Human MICAL2 shRNA Plasmid

Ask
View Details
Human MICAL2 shRNA Plasmid
abx956422-02 300 µg

Human MICAL2 shRNA Plasmid

Ask
View Details
Mouse Monoclonal Calbindin D-28K Antibody (CALB1/3333) [Janelia Fluor 549]
NBP3-08322JF549 100 µL

Mouse Monoclonal Calbindin D-28K Antibody (CALB1/3333) [Janelia Fluor 549]

Ask
View Details
Phospho-HS1 (Tyr378/397) (D12C1) XP® Rabbit Monoclonal Antibody
CST 8714T 20 µL

Phospho-HS1 (Tyr378/397) (D12C1) XP® Rabbit Monoclonal Antibody

Ask
View Details
RGD1305207 AAV Vector (Rat) (CMV)
38930106 1 μg

RGD1305207 AAV Vector (Rat) (CMV)

Ask
View Details