Hyaluronic acid

Hyaluronic acid is a biopolymer composed of repeating units of disaccharides with various applications. Hyaluronic acid is a major component of the extracellular matrix (ECM) . Hyaluronic acid is synthesized at the plasma membrane. Increased hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion and angiogenesis in digestive cancers. Hyaluronic acid participates in tissue remodeling and rapid cell proliferation in some physiological processes including embryonic morphogenesis and wound-healing. Hyaluronic acid activates the PI3K-Akt signaling. Hyaluronic acid acts as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid also enhances cell invasion and angiogenesis by promoting proteolytic MMP-9 binding to cell surface or stimulating MMP-9 binding to cell surface. Hyaluronic acid can be used as drug delivery for sodium butyrate to improve the anti-proliferative activity on breast cancer cell line. Hyaluronic acid can be studied in joint diseases, wound healing and cancer[1][2][3][4][5].

Product Specifications

CAS Number

[9004-61-9]

Product Name Alternative

Hyaluronan; Hyaluronate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; Bacterial; Endogenous Metabolite; PI3K

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Hyaluronic-acid.html

Purity

97.0

Solubility

DMSO : < 1 mg/mL|H2O : 8.33 mg/mL (ultrasonic)

Smiles

CCC1[C@@H](O)[C@@H](O)O[C@@H](O[C@H]2[C@H](C(O)=O)OC(OC)[C@@H](O)[C@@H]2O)[C@@H]1NC(C)=O.[n]

Molecular Formula

(C14H21NO11) n

Molecular Weight

379.32 (monomer)

Precautions

H302, H315, H319, H335

References & Citations

[1]Salwowska NM, et al. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol. 2016 Dec;15 (4) :520-526.|[2]Wu RL, et al. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017 Jan;143 (1) :1-16.|[3]Kogan G, et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007 Jan;29 (1) :17-25.|[4]Coradini, D., et al., (1999) . Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line. International journal of cancer, 81 (3), 411–416. |[5]Goa, K. L., & Benfield, P. (1994) . Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs, 47 (3), 536–566.