Shikonin
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM[1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor[2] and can also inhibit TNF-α and NF-κB pathway[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis[4]. Shikonin inhibits AIM2 inflammasome activation[7].
Product Specifications
CAS Number
517-89-5
Product Name Alternative
C.I. 75535; Isoarnebin 4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AIM2; Chloride Channel; HIV; NF-κB; Pyruvate Kinase; TNF Receptor
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Shikonin.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O
Molecular Formula
C16H16O5
Molecular Weight
288.30
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NF-κB; TNFRSF5/CD40
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Mix-n-StainTM CF®532 Antibody Labeling Kit, 1x (5-20ug) labeling
CD63 (Late Endosomes Marker) (LAMP3/2990R), CF594 conjugate, 0.1mg/mL
