Pyridinium bisretinoid A2E (TFA)

Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE) . Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases[1][2].

Product Specifications

CAS Number

[1821308-73-9]

Product Name Alternative

A2E (TFA) ; N-retinylidene-N-retinylethanolamine (TFA)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyridinium-bisretinoid-a2e-tfa.html

Purity

90.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C.O=C([O-])C(F)(F)F

Molecular Formula

C44H58F3NO3

Molecular Weight

705.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555. |[2]S. Ben-Shabat, et al; Elucidating the Role of Pyridinium bis-Retinoid (A2E) in Retinal Pigment Epithelium (RPE) Cell Damages. Invest. Ophthalmol. Vis. Sci. 2007;48 (13) :2201. |[3]Sokolov VS, et al. Interaction of pyridinium bis-retinoid (A2E) with bilayer lipid membranes. J Photochem Photobiol B. 2007 Feb 1;86 (2) :177-85.