DMCM (hydrochloride)

DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively[1].

Product Specifications

CAS Number

[1215833-62-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/DMCM-hydrochloride.html

Purity

99.07

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(C1=C(CC)C2=C(C=N1)NC3=C2C=C(OC)C(OC)=C3)OC.[H]Cl

Molecular Formula

C17H19ClN2O4

Molecular Weight

350.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47 (24) :5829-32.|[2]Leppä E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA (A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48 (4) :469-78.