JO146
Product Specifications
UNSPSC Description
JO146 is a Chlamydia trachomatis high temperature requirement A (CtHtrA) protease inhibitor with IC50s of 21.86 and 1.15 μM for CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibits bacterial infections[1].
Target Antigen
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/jo146.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)N[C@@H](C(C)C)C(N1[C@H](C(NC(P(OC2=CC=CC=C2)(OC3=CC=CC=C3)=O)C(C)C)=O)CCC1)=O
Molecular Weight
601.67
References & Citations
[1]Jimin Hwang, et al. Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in <i>Chlamydia</i>. Eur J Med Chem. 2022 Feb 15;230:114064.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144820/JO146-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144820/JO146-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
130727-21-8
Available Sizes
Curated Selection
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