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INO-1001

INO-1001 is a potent and selective poly (ADP-ribose) polymerase (PARP) inhibitor. INO-1001 is a potent enhancer of radiation sensitivity and enhances radiation-induced cell killing by interfering with DNA repair mechanisms, resulting in necrotic cell death[1]. INO-1001 has anti-tumor effects[2].

Product Specifications

CAS Number

[501364-82-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ino-1001-1.html

Purity

98.86

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C3=CC=CC=C31)CC4=C2C=CC(S(NCCCN5CCOCC5)(=O)=O)=C4

Molecular Formula

C23H25N3O4S

Molecular Weight

439.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly (ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205 (2) :155-60.|[2]Mason KA, et al. INO-1001, a novel inhibitor of poly (ADP-ribose) polymerase, enhances tumor response to doxorubicin. Invest New Drugs. 2008 Feb;26 (1) :1-5. Epub 2007 Jul 13.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

PARP

Available Sizes

Curated Selection

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