10074-G5
C-Myc inhibitor
Product Specifications
Background
10074-G5 binds to and distorts the bHLH-ZIP domain of c-Myc, thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (1). 10074-G5 is capable of binding and sequestering the intrinsically disordered amyloid-β (Aβ) peptide in its monomeric, soluble state. Our analysis reveals that this compound interacts with Aβ and inhibits both the primary and secondary nucleation pathways in its aggregation process (2).
CAS Number
413611-93-5
Product Name Alternative
7-Nitro-N- (2-phenylphenyl) -2,1,3-benzoxadiazol-4-amine
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Amyloid | Tags and Cell Markers | Epitope Tags | Myc Tag
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Orange powder
Solubility
May be dissolved in DMSO (40 mg/ml)
Molecular Formula
C18H12N4O3
Molecular Weight
332.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Follis A.V. et al. (2008) Chem. Biol. 15: 1149. 2. Heller G.T. (2020) ScienceAdvances. 6(45): DOI: 10.1126/sciadv.abb5924.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP312539L 1 mg
Carbonic anhydrase X (CA10) (NM_001082534) Human Recombinant Protein
Sign In for Pricing
View Details 
BNUB2282-100 1x 100 µL
Phospho C-Jun (Thr91, Thr93) (C-J 4C4/1), 0.2mg/mL
Sign In for Pricing
View Details 
PKSH033858-01 10 µg
Recombinant Human CD27 Ligand/TNFSF7/CD70 (C-mFc)
Sign In for Pricing
View Details PKSH033858-02 50 µg
Recombinant Human CD27 Ligand/TNFSF7/CD70 (C-mFc)
Sign In for Pricing
View Details 