10074-G5
c-Myc inhibitor
Product Specifications
Background
10074-G5 binds to and distorts the bHLH-ZIP domain of c-Myc, thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (1). 10074-G5 is capable of binding and sequestering the intrinsically disordered amyloid-β (Aβ) peptide in its monomeric, soluble state. Our analysis reveals that this compound interacts with Aβ and inhibits both the primary and secondary nucleation pathways in its aggregation process (2).
Product Name Alternative
7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
UNSPSC
41116105
Source
Synthetic
Purity
>98% (TLC); NMR (Conforms)
Weight
0.005
Format
Orange powder
Solubility
May be dissolved in DMSO (40 mg/ml)
Molecular Formula
C18H12N4O3
Molecular Weight
332.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Follis A.V. et al. (2008) Chem. Biol. 15: 1149. 2. Heller G.T. (2020) ScienceAdvances. 6(45): DOI: 10.1126/sciadv.abb5924.
CAS Number
413611-93-5
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