TTNPB
Retinoic acid receptor agonist
Product Specifications
Background
TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors (1). Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Tranylcypromine, Valproic Acid, 3-Deazaneplanocin A, and E-616452 (2). And it Induces the in vitro growth and differentiation to granulocytes of myeloid progenitors isolated from myelodysplastic syndrome (MDS) patients (3).
CAS Number
71441-28-6
Product Name Alternative
4-[ (E) -2- (5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) -1-propenyl]benzoic acid; Ro 13-7410; AGN-191183
UNSPSC
41116105
Type
Agonist
Source
Synthetic
Field of Research
Cancer | Apoptosis | Stem Cells
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (4 mg/ml)
Molecular Formula
C24H28O2
Molecular Weight
348.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Beard R.L., et al. (1995) J Med Chem. 38 (15): 2820-2829. 2. Hou P. et al. (2013) Science. 341 (6146): 651-654. 3. Fabian I. (1987) Leukemia Research. 11 (7): 635-640.
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