Aphidicolin
DNA polymerase inhibitor
Product Specifications
Background
Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases (1). Arrests cell cycle at early S phase while allowing continued cell growth(2). Potentiates apoptosis induction induced by other agents(3). Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2(4).
CAS Number
38966-21-1
Product Name Alternative
(3R,4R,4aR,6aS,8R,9R,11aS,11bS) -Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol; (from Nigrospora sp.)
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Neuroscience
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml)
Molecular Formula
C20H34O4
Molecular Weight
338.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Syvaoja J., et al. (1990) Proc. Natl. Acad. Sci. USA. 87(17):6664-6668.
2. Urbani L., et al. (1995) Exp. Cell Res. 219(1):159-168.
3. Kuwakado K., et al. (1993) Biochem. Pharmacol. 46:1909-1916.
4. Yin D.X., and Schimke R.T. (1996) Proc. Natl. Acad. Sci. USA. 93:3394-3398.
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