AM 580
Rar agonist
Product Specifications
Background
AM-580, a benzoic derivative of retinoic acid and a selective RAR-α agonist, has been shown to significantly reduce the production of Th1 cytokines but promote Th2 cytokines in human PBMCs7 and to inhibit microglial activation, thus acting beneficially in Alzheimer's disease treatment. It also is known to inhibit tumor cell proliferation and induces apoptosis.
CAS Number
102121-60-8
Product Name Alternative
4-[ (5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055
UNSPSC
41116105
Type
Agonist
Source
Synthetic
Field of Research
Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Neuroscience | Cancer | Oxidative Stress | Neurodegeneration | Alzheimer's Disease
Purity
>98% (HPLC) NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml)
Molecular Formula
C22H25NO3
Molecular Weight
351.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wang O., Thome R., Rostami A., Ma C-G., Zhang G-X. (2019) Nature. 16: 727-729. 2. Bosch A., et al. (2012) Breast Cancer Res. 14(4): R121.
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