KNK 437
HSP70 Inhibitor
Product Specifications
Background
KNK 437 is an inhibitor of the acquisition of thermotolerance caused by the induction of HSPs, including HSP105, HSP70, and HSP40 in human colon carcinoma cells (1). It has also been tested in anti-tumor therapy of colorectal cancer (2).
CAS Number
218924-25-5
Product Name Alternative
3- (1,3-Benzodioxol-5-ylmethylene) -2-oxo-1-pyrrolidinecarboxaldehyde
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (30 mg/ml)
Molecular Formula
C13H11NO4
Molecular Weight
245.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yokota S., Kitahara M., and Nagata K. (2000) Cancer Res. 60 (11): 2942-2948. 2. Yang S., et al. (2020) Oncogene. 39: 249-261.
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