5-Ethynyl-2’-deoxyuridine
DNA labeling agent
Product Specifications
Background
5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine that is used to monitor DNA synthesis through click chemistry (1). Unlike 5-bromo-2’-deoxyuridine (BrdU), EdU does not require sample fixation or DNA denaturation. It can then be detected using a fluorescent azide probe and copper catalysis using 1,3-dipolar cycloaddition.
CAS Number
61135-33-9
Product Name Alternative
2'-Deoxy-5-ethynyluridine; 5-EdU; 5-Ethynyl-2'-deoxyuridine; EdU
UNSPSC
41116105
Type
Labelling Agent
Source
Synthetic
Field of Research
Cancer | Oxidative Stress | Cell Signaling | Post-translational Modifications | Oxidation | Cell Signaling | Epigenetics and Nuclear Signaling | DNA/RNA | DNA Damage and Repair
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (10 mg/ml)
Molecular Formula
C11H12N2O5
Molecular Weight
252.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Salic A., and Mitchison, T.J. (2008) Proc. Natl. Acad. Sci. USA. 105:2415.
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