Z-Guggulsterone
FXR Antagonist
Product Specifications
Background
Z-Guggulsterine acts as a selective antagonist at farnesoid X receptors, and inhibits FXR transactivation. It is also a retinoic acid receptor (RAR) pathway inhibitor. Attenuates astrocyte-mediated neuroinflammation by inhibiting toll-like receptor 4 pathway.
CAS Number
39025-23-5
Product Name Alternative
(Z) -Pregna-4,17 (20) -diene-3,16-dione
UNSPSC
41116105
Type
Antagonist
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | NFkB Pathway | Neuroscience | Neuroinflammation
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Off-white powder
Solubility
May be dissolved in DMSO (6 mg/ml, warm); or Ethanol (3 mg/ml, warm)
Molecular Formula
C21H28O2
Molecular Weight
312.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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