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Camostat mesylate

Serine protease inhibitor

Product Specifications

Background

Camostat mesylate is an orally active protease inhibitor. It inhibits the serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (Covid-19) into lung cells and Human coronavirus NL63 into HeLa cells. It has also been used in some cancer treatments, against viral infections, and for inhibiting fibrosis in liver, kidney disease and pancreatitis.

CAS Number

59721-29-8

Product Name Alternative

4-[[4-[ (Aminoiminomethyl) amino]benzoyl]oxy]benzeneacetic acid 2- (dimethylamino) -2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Cell Signaling

Purity

>98% (HPLC) ; NMR (Conforms)

Weight

0.005

Format

Off-white powder

Solubility

May be dissolved in DMSO (50 mg/mL) or Water (50mg/mL)

Molecular Formula

C20H22N4O5·CH3SO3H

Molecular Weight

494.5

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Okuno M., et al. (2002). Front Biosci. 7 (4): d204-218. 2. Hsieh H. P., Hsu, J. T. (2007). Current Pharmaceutical Design. 13 (34): 3531–3542. 3. Kitamura K., Tomita K. (2012). Clinical and Experimental Nephrology. 16 (1): 44–48. 4. Kawase M., Shirato K., van der Hoek L., Taguchi F., Matsuyama S. (2012) J Virol. 86(12): 6537-6545. 5.. Hoffman M., et al. (2020) Cell: https://doi.org/10.1016/j.cell.2020.02.052

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