5-Fluoroorotic acid

5-Fluoroorotic acid is the inhibitor for thymidylate synthase that acts as a selective agent in yeast molecular genetics. 5-Fluoroorotic acid exhibits antimalarial activity[1][2][3].

Product Specifications

CAS Number

[703-95-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite; Thymidylate Synthase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/5-fluoroorotic-acid.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C(NC1=O)=C(F)C(N1)=O)O

Molecular Formula

C5H3FN2O4

Molecular Weight

174.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Boeke JD, et, al. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 1987; 154: 164-75.|[2]Nikolova K, et, al. Studies on the antimycotic activity of 5-fluoroorotic acid. Methods Find Exp Clin Pharmacol. 1987 Feb; 9 (2) : 85-9.|[3]Santoso D, et al., Fluoroorotic acid-selected Nicotiana plumbaginifolia cell lines with a stable thymine starvation phenotype have lost the thymine-regulated transcriptional program. Plant Physiol. 2000 Aug;123 (4) :1517-24.|[4]Rathod PK, et al., Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1989 Jul;33 (7) :1090-4. |[5]Gómez ZM, et al., Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. Antimicrob Agents Chemother. 1990 Jul;34 (7) :1371-5.