Tau Antibody: APC

Tau is a microtubule-associated protein encoded by the MAPT gene and plays a vital role in stabilizing neuronal microtubules. In Alzheimer’s disease (AD) and related tauopathies, tau undergoes pathological modifications that lead to its aggregation into paired helical filaments (PHFs), forming neurofibrillary tangles—a hallmark of AD. A truncated tau fragment comprising residues 297–391, known as Tau dGAE, represents a minimal core region capable of self-assembling into PHF-like fibrils in vitro without the need for cofactors or templates. This 95-amino acid segment has been identified in the core of PHFs extracted from AD brain tissue and forms filaments that closely mimic those observed in human pathology. Tau dGAE is a powerful model for studying the molecular mechanisms of tau aggregation, seeding, and propagation. Its ability to recapitulate key structural features of pathological tau makes it an essential tool for developing aggregation inhibitors, imaging agents, and immunotherapies targeting tau fibrils. By isolating the aggregation-prone core of tau, researchers can dissect the structural transitions and biochemical interactions that drive neurodegeneration, making Tau dGAE a critical focus in Alzheimer’s disease research and therapeutic development.

Tau, MAPT, Microtubule-associated protein tau, Microtubule associated protein tau, Microtubule associated protein tau isoform 4, TAU_HUMAN, TAU, MAPTL, MTBT1, MTBT2, RNPTAU, PHF-tau, PHF tau, Paired helical filament tau, Paired helical filament-tau, Neurofibrillary tangle protein, DDPAC, FTDP 17, MSTD, PPND, PPP1R103, Protein phosphatase 1 regulatory subunit 103, G protein beta1/gamma2 subunit interacting factor 1, AI413597, AW045860, FLJ31424, MGC134287, MGC138549, MGC156663, dGAE tau fibril, Truncated Tau Fragment (AA297-391), 95-amino acid tau protein fragment, Truncated Tau Protein

Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex

Alzheimer's Disease | Axon Markers | Cell Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins | Neurodegeneration | Neuron Markers | Neuroscience | Tangles & Tau

A 1:1000 dilution of SPC-806 was sufficient for detection of tau in 15 μg of mouse, rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146–148 (1907) 3. Al-Hilaly, Y.K. et al. Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking. J. Mol. Biol. 429 (23) :3650-3665 (2017)

Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex