Tau Antibody (pThr217), Clone 15B7

Tau, encoded by the MAPT gene, is a microtubule-associated protein critical for maintaining neuronal structure and axonal transport. The MAPT transcript undergoes complex alternative splicing, producing six isoforms in the adult human brain. These isoforms are differentially expressed depending on neuronal type and developmental stage, reflecting tau’s dynamic role in neural function. In neurodegenerative diseases such as Alzheimer’s disease (AD), tau becomes abnormally phosphorylated, leading to its detachment from microtubules and aggregation into neurofibrillary tangles. Among the many phosphorylation sites, threonine 217 (pThr217) has emerged as a highly specific and early biomarker of AD pathology. Phosphorylation at Thr217 correlates strongly with amyloid-β burden and cognitive decline, making it a valuable target for early diagnosis and disease monitoring. Unlike other phospho-tau epitopes, pThr217 shows high diagnostic accuracy in cerebrospinal fluid and plasma, and is increasingly used in biomarker panels for AD. Tau (pThr217) provides insight into the molecular mechanisms driving tauopathy progression. Its specificity and accessibility make it a promising candidate for therapeutic targeting and longitudinal tracking in neurodegenerative disease research.

Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Cell Markers | Neuron Markers | Axon Markers | Cell Signaling | Cytoskeleton | Microtubules | MT Associated Proteins

A 1:1000 dilution of SMC-615 was sufficient for detection of Tau in 10 µg of Human, Mouse, Rat Tau Peptide (pThr217) by DB analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.