RAB3D Antibody, Clone 5E9

Mouse Anti-Human RAB3D Monoclonal IgG1

Product Specifications

Background

RAB3D is a member of the Rab family of small GTPases involved in regulated exocytosis. It plays a role in vesicle trafficking from the trans-Golgi network and is essential for protein secretion in various cell types. Although best known for its function in osteoclast-mediated bone resorption, RAB3D is also expressed in the nervous system, where it may influence synaptic vesicle dynamics and neurotransmitter release. Given the importance of vesicle trafficking in neuronal communication, dysregulation of RAB3D could contribute to synaptic dysfunction in neurodegenerative diseases. Its role in exocytosis makes it a candidate for further investigation in disorders characterized by impaired synaptic transmission.

CAS Number

9007-83-4

Specifications

Detects ~24 kDa. Does not show cross reactivity to RAB3A, RAB3B, or RAB3C.

Product Name Alternative

Member RAS Oncogene Family, D2-2, GOV, RAB16, RAD3D, Ras-Related Protein Rab-3D

Synonyms

RAB3D Antibody, Clone 5E9

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

9545

Swiss Prot

O95716

Accession Number

NP_004274

Cellular Locus

Cell membrane, Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Full length recombinant Human RAB3D protein

Target

RAB3D

Clonality

Monoclonal

Isotype

IgG1

Clone

5E9

Conjugation

Unconjugated

Type

Monoclonal

Applications

Validated Applications

Field of Research

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-614 was sufficient for detection of RAB3D in 10 µg of A549, T-47D cells, mouse and rat brain, kidney by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.

Concentration

1mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhu, S. et al. (2016) Sci Rep. 6:37963 2. Pavlos, N. J. et al. (2005) Mol Cell Biol. 25(12): 5253–5269

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects ~24 kDa. Does not show cross reactivity to RAB3A, RAB3B, or RAB3C.

Background Reference 01

1. Zhu, S. et al. (2016) Sci Rep. 6:37963 2. Pavlos, N. J. et al. (2005) Mol Cell Biol. 25 (12) : 5253–5269

Species

Human | Mouse | Rat

Location

Cell membrane, Membrane

Isotype

IgG1

Immunogen Species

Human

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