NNOS Antibody, Clone J23

Mouse Anti-Human NOS1/nNOS Monoclonal IgG2a

Product Specifications

Background

Neuronal nitric oxide synthase (NOS1 or nNOS) is a constitutive enzyme responsible for producing nitric oxide (NO), a gaseous neurotransmitter involved in synaptic plasticity, neurovascular coupling, and neuroprotection. NOS1 catalyzes the oxidation of L-arginine to L-citrulline and NO, modulating intracellular signaling cascades. In neurodegenerative diseases, dysregulated NOS1 activity contributes to oxidative stress, mitochondrial dysfunction, and excitotoxicity. Excessive NO production can lead to peroxynitrite formation and protein nitration, exacerbating neuronal injury. Targeting NOS1 and its downstream pathways offers potential for therapeutic intervention in conditions such as Alzheimer’s disease, Parkinson’s disease, and ALS.

CAS Number

9007-83-4

Specifications

Detects ~160.97 kDa.

Product Name Alternative

BNOS, Constitutive NOS, IHPS 1, IHPS1, N-NOS, NC-NOS, neuronal Nitric Oxide Synthase, Neuronal NOS, Nitric oxide synthase neuronal included, Nitric oxide synthase 1 (neuronal), Nitric oxide synthase 1, NNOS, NO, NOS 1, NOS, NOS type I, NOS-I, NOS1, NOS1_HUMAN

Synonyms

NOS1/ nNOS Antibody

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

4842

Swiss Prot

P29475

Accession Number

NP_000611.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Partial Human Recombinant NOS1 Protein

Target

NOS1

Clonality

Monoclonal

Isotype

IgG2a

Clone

J23

Conjugation

Unconjugated

Tissue Specificity

Ubiquitously expressed; detected in skeletal muscle and brain, also in testis, lung and kidney.

Type

Monoclonal

Applications

WB | ICC/IF | ELISA | IHC

Validated Applications

WB,ICC/IF,ELISA,IHC

Field of Research

Purification

Protein A Purified

Limit Of Detection

A 1:1000 dilution of SMC-609 was sufficient for detection of NOS1/Nnos in 7.5 ug of Mouse Brain Cerebellum by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.