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NNOS Antibody, Clone J23: APC

Mouse Anti-Human NOS1/nNOS Monoclonal IgG2a

Product Specifications

Background

Neuronal nitric oxide synthase (NOS1 or nNOS) is a constitutive enzyme responsible for producing nitric oxide (NO), a gaseous neurotransmitter involved in synaptic plasticity, neurovascular coupling, and neuroprotection. NOS1 catalyzes the oxidation of L-arginine to L-citrulline and NO, modulating intracellular signaling cascades. In neurodegenerative diseases, dysregulated NOS1 activity contributes to oxidative stress, mitochondrial dysfunction, and excitotoxicity. Excessive NO production can lead to peroxynitrite formation and protein nitration, exacerbating neuronal injury. Targeting NOS1 and its downstream pathways offers potential for therapeutic intervention in conditions such as Alzheimer’s disease, Parkinson’s disease, and ALS.

Specifications

Detects ~160.97 kDa.

Product Name Alternative

BNOS, Constitutive NOS, IHPS 1, IHPS1, N-NOS, NC-NOS, neuronal Nitric Oxide Synthase, Neuronal NOS, Nitric oxide synthase neuronal included, Nitric oxide synthase 1 (neuronal), Nitric oxide synthase 1, NNOS, NO, NOS 1, NOS, NOS type I, NOS-I, NOS1, NOS1_HUMAN

Synonyms

NOS1/ nNOS Antibody: APC

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

4842

Swiss Prot

P29475

Accession Number

NP_000611.1

Cellular Locus

Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Partial Human Recombinant NOS1 Protein

Target

NOS1

Clonality

Monoclonal

Isotype

IgG2a

Clone

J23

Conjugation

APC

Tissue Specificity

Ubiquitously expressed; detected in skeletal muscle and brain, also in testis, lung and kidney.

Type

Monoclonal

Applications

WB | ICC/IF | ELISA | IHC

Validated Applications

IHC,ICC/IF

Field of Research

Neuroscience | Neurotransmission | Nitric Oxide | Cancer | Cancer Metabolism | Response to Hypoxia

Purification

Protein A Purified

Limit Of Detection

A 1:1000 dilution of SMC-609 was sufficient for detection of NOS1/Nnos in 7.5 ug of Mouse Brain Cerebellum by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1mg/ml

Dilution

WB (1:1000) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Product Datasheet

https://www.stressmarq.com/wp-content/uploads/2015/05/APC-Fluorescent-conjugate.pdf

Product MSDS

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Specificity

Detects ~160.97 kDa.

Species

Human | Mouse | Rat

CAS Number

9007-83-4

Location

Cell Membrane

Isotype

IgG2a

Immunogen Species

Human

Curated Selection

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