AI-10-49

AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC50 value of 0.26 μM. AI-10-49 can be used for the research of leukemia[1].

Product Specifications

CAS Number

[1256094-72-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

RUNX

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/AI-10-49.html

Purity

99.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(F)OC1=CC=C2N=C(C3=NC=C(OCCOCCOC4=CN=C(C5=NC6=CC=C(OC(F)(F)F)C=C6N5)C=C4)C=C3)NC2=C1

Molecular Formula

C30H22F6N6O5

Molecular Weight

660.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Anuradha Illendula, et al. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347 (6223) :779-84.