WZ811
Product Specifications
UNSPSC Description
WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM)[1].
Target Antigen
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/wz811.html
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1
Molecular Weight
290.36
References & Citations
[1]WZ811, et al. Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64.|[2]Li SH, et al. Suppression of chronic lymphocytic leukemia progression by CXCR4 inhibitor WZ811. Am J Transl Res. 2016 Sep 15;8(9):3812-3821.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15478/WZ811-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15478/WZ811-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
55778-02-4
Available Sizes
Curated Selection
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