Eleclazine (hydrochloride)
Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of [1][2][3].
Product Specifications
CAS Number
1448754-43-5
Product Name Alternative
GS 6615 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Eleclazine-hydrochloride.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13.[H]Cl
Molecular Formula
C21H17ClF3N3O3
Molecular Weight
451.83
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Am J Transl Res. 2020 Jul 15;12 (7) :3822-3841. |Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19;378 (1879) :20220163.
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