B-Raf IN 1

B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

Product Specifications

CAS Number

[950736-05-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/B-Raf-IN-1.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 65 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5

Molecular Formula

C29H24F3N5O

Molecular Weight

515.53

Precautions

H302

References & Citations

[1]Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19 (23) :6519-23.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

B-Raf

Available Sizes

Curated Selection

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