B-Raf IN 1
Product Specifications
UNSPSC Description
B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.
Target Antigen
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/B-Raf-IN-1.html
Purity
99.94
Solubility
DMSO : 65 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(C2=CC=NC3=C(C4=CC=C(CN(C)C)C=C4)C=NN23)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Weight
515.53
References & Citations
[1]Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18227/B-Raf-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18227/B-Raf-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
950736-05-7
Available Sizes
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